At Squarespace, I had to write automated tests for a css/js heavy website and that couldn't be done using just Selenium. Once I integrated Sikuli with Selenium, I was able to do get the job done. I had best of both worlds. I hosted a meetup at AOL/Huff Post office in NYC to talk about Sikuli and explain its benefits. The presentation is below:
There are 6 reasons to integrate selenium with sikuli.
All about that is explained here.
Feedback received from the folks (40ish) in the room. Before and after the presentation: